ATT Dosage Adjustments for Organ Dysfunction - Know Your Drugs! 💡 Our first-line Anti-Tubercular Therapy (ATT) regimen relies on four key drugs: Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), and Ethambutol (E). But managing these drugs in patients with organ dysfunction is crucial. Here's a breakdown: 1. Hepatotoxic Drugs (H, R, Z): Isoniazid, Rifampicin, and Pyrazinamide are all metabolized by the liver and are known to be hepatotoxic. Clinical Pearl: In patients with liver dysfunction, you