There isn’t a lot of formal research specifically linking iron infusions to altered HRT effects, after some reading and thought there are some plausible that may explain what’s happening. 1. Iron infusions and oestrogen metabolism ✅Iron is a cofactor in liver enzyme systems (particularly cytochrome P450 enzymes) involved in oestrogen metabolism. → After an infusion, as ferritin and transferrin saturation rise, liver enzyme activity can temporarily shift meaning oestrogen might be metabolised dif