Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. Traditionally, phase separation directly regulates cell functions by driving RNA, ...

Ripples allow for the existence of two-dimensional (2D) materials and significantly influence their properties. Introducing defects is a common strategy to modulate the material’s morphology for ...

Agriculture is one of the main drivers of global land use change (LUC) as well as terrestrial carbon and biodiversity losses. While the environmental footprint from agricultural production could be ...

US municipal wastewater facilities are major per- and polyfluoroalkyl substances (PFAS) sources known to affect drinking water quality. Among eight large wastewater treatment facilities with ...

Reports of soil organic carbon (SOC) dynamics in China’s croplands vary substantially due to diverse data sources and the lack of a standardized methodology. Additionally, SOC dynamics in deeper soil ...

Soils contain the largest pool of organic carbon near the surface of the Earth and represent a natural carbon sink that helps to buffer against anthropogenic carbon emissions and land-use changes.

Contributed by Carl H. June; received November 13, 2023; accepted February 1, 2024; reviewed by Yizhou Dong and John O’Shea The use of lipid nanoparticles (LNP) to encapsulate and deliver mRNA has ...

S-palmitoylation is a lipid posttranslational modification process involved in diverse cellular events in a wide range of biological systems. It has remained unclear whether S-palmitoylation has a ...

Calcium enters mitochondria via the calcium uniporter to regulate energy production and survival. The uniporter activity is controlled by calcium via binding the EF-hands of the regulatory MICU ...

The PNAS Editorial Board is made up of NAS members who are active scientists and experts in their fields. On submission, your paper is assigned to an Editorial Board member in one of the 31 NAS ...

Healthy brain function requires a delicate balance of neural excitation (E) and inhibition (I). In animals, this balance—the E/I ratio—is known to decrease with the maturation of inhibitory circuitry ...

The generation of fusion kinases through gene rearrangement represents a primary mechanism of rearranged during transfection (RET) oncogenic conversion. The change of location, increased expression, ...