The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained.

A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during fever. Laboratory tests showed an elevated ESR and elevated ...

It is regrettable that pulmonary embolism as a discrete cause of sudden cardiac arrest in athletes is not addressed by Lampert and Harmon’s recent review (Jan. 15 issue).1 In an ...

Post-thrombotic syndrome is common after deep-vein thrombosis and can cause severe symptoms involving the limbs that impair patients’ activity and quality of life. Endovascular therapy can ...

Abstract In this second of two Health Policy Reports marking the 10th anniversary of the Affordable Care Act, the authors describe major payment and delivery system reforms and analyze the available ...

Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA ...

Findings from an analysis of deidentified electronic health record data from a national database indicate that the prevalence of youth-onset type 2 diabetes has increased substantially during the p ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 13).

Douglas Opel is a professor in the Department of Pediatrics at the University of Washington School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal.

This feature about acute liver failure on the background of alcohol-associated cirrhosis offers a case vignette accompanied by two essays, one recommending liver transplantation and the other ...

To the Editor: In their Clinical Practice article on functional dyspepsia, Pasricha and Talley (Jan. 8 issue)1 devote limited attention to prokinetic drugs. This choice is puzzling, given the frequ ...

To the Editor: In their Image in Clinical Medicine, Rodriguez-Lechtig and Motta (April 10 issue)1 report a case of pemphigus foliaceus. The exfoliative erythroderma and subcorneal vesicles are char ...