The United States faces a projected shortage of millions of long-term–care workers by 2040. Yet in each area where progress could help address this gap, federal policy is moving in the wrong direction ...

Explore the current issue of The New England Journal of Medicine (Vol. 395 No. 1).

Five of the 56 signatories of the American Declaration of Independence were doctors, a high-water mark in the history of medical representation in American political leadership. This is the third in a ...

To the Editor: In the phase 3 GRADUATE trials of gantenerumab for early Alzheimer’s disease reported by Bateman et al. (Nov. 16 issue), 1 participants receiving gantenerumab had a greater decrease in ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 24).

To the Editor: In the SMART-DECISION trial, Choi and colleagues (April 2 issue) 1 evaluated the discontinuation of beta-blocker therapy after myocardial infarction in patients with a left ventricular ...

A 47-year-old man with heart failure with a reduced ejection fraction and an ICD for the primary prevention of sudden cardiac death presented with an unheralded syncopal event, which had been captu ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 23).

Hemorrhagic shock remains the leading cause of preventable death after injury. 1 Over the past two decades, early administration of blood products has transformed care for patients with bleeding. The ...

Hereditary angioedema is a rare and potentially life-threatening genetic condition characterized by recurrent and debilitating swelling attacks. Lonvoguran ziclumeran (lonvo-z) — an investigational, ...

Talquetamab, a bispecific antibody targeting GPRC5D and CD3, has led to durable responses in patients with heavily pretreated relapsed or refractory multiple myeloma in phase 1–2 trials, with a ...

In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing.