Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

Besides cushioning the brain, CSF washes away waste such as neurotransmitters, metabolites, and proteins, including proteins that aggregate—such as Aβ and tau. After circulating through the brain, CSF ...

Because hypertension is linked to a greater risk of dementia, several trials have investigated whether lowering blood pressure in older people would protect the brain. Data from cohorts of a few ...

Summary The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

For years, scientists have been working toward blood tests for Alzheimer’s disease that could be used routinely in clinical practice. Now, they are on the cusp. At this year’s ADPD conference, held ...

When teamed up with its partner, the retromer complex, SORL1 carries all manner of precious protein cargo through the endolysosomal system to the cell surface, and back again. With such a busy life, ...

Of the 20,000+ human genes, none has greater influence on late-onset Alzheimer’s disease than APOE. But why do certain variants of this lipid transporter protect the brain, while others endanger it? A ...

Since the discovery that two copies of ApoE3-R136S (formally R154S) seemed to sever the tie between amyloid and tau pathologies, scientists have been digging for the mechanisms (Nov 2019 news; Sep ...

Old drugs die hard. Despite a string of negative Phase 3 trials, HMTM, a derivative of the malaria drug methylene blue, resurfaced again at AD/PD 2024, held March 5-9 in Lisbon, Portugal. TauRx CEO ...

Not so long ago, a blood test for Alzheimer’s disease seemed a pipe dream. Now, after years of study, the field is awash with sensitive assays that signal the proteopathic culprits Aβ and tau ...