Synonyms: G2-3(A53T), PrPsynA53T, A53TαS Tg mice (line G2-3), MoPrP-Huα-Syn(A53T), Hualpha-Syn(A53T), A53T aSyn Tg Mouse (Lee), alpha-synuclein A53T Mouse (Tg) ...

This month marks three years since lecanemab received traditional approval from U.S. regulators, opening the door to widespread use. At the Alzheimer’s Association International Conference, held in ...

Baylor College of Medicine Baylor College of Medicine, Department of Neurology 6501 Fannin St., NB320 Houston, TX77030 United States Visit Website Contact: Dr. Joshua M. Shulman, Director Phone: (713) ...

Researchers propose unifying TDP-43 proteinopathies under one umbrella. TDP-43-associated neurodegenerative disease (TAND) would include ALS, FTD, and LATE. A machine learning algorithm, MARBLE, ...

A blood test may be almost as good as a brain scan for determining where someone lies along the Alzheimer’s disease continuum. So conclude scientists led by Gemma Salvadó and Oskar Hansson at Lund ...

Two New Tau Therapies Move to Phase 3 PSP Trials PI-2620 Tracks Tau Changes in PSP—Ready for Trials? One Tau Structure, One Disease? If Only It Were That Simple Tau Fibrils Ensnare the RNA-Binding ...

At this year’s Alzheimer’s Association International Conference, held July 27-31 in Toronto, scientists introduced a plethora of new assays for biomarkers that could improve diagnosis and tracking of ...

As the trained killers of the immune system, cytotoxic T cells silently save our lives every day—vanquishing viruses before they can run amok, and putting nascent cancer cells out of business before ...

These mice are deficient in PSEN1. This model is perinatal lethal in homozygouse animals which die shortly after birth, presumably from breathing difficulties due to ribcage deformity (Shen et al., ...

Summary These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, C3-3, was generated in parallel with ...

Talk about a closely watched study. Conference after conference, Roche scientists running the ongoing Brain Shuttle AD trial of trontinemab are dispensing morsels of news from sequential interim ...

Signaling through the TREM2 receptor fuels an ever-growing list of known microglial functions in the brain, and gene variants that hobble TREM2 signaling beckon Alzheimer’s disease. Ergo, activating ...