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综述:20世纪前药物人体试验与医学伦理发展史 - 生物通
19世纪化学工业催生药理学革命:弗里德里希·塞尔杜纳(Friedrich Sertürner)1804年从鸦片分离吗啡,引发镇痛药研发浪潮;皮埃尔·佩尔蒂埃(Pierre-Joseph Pelletier)1820年提取奎宁生物碱。 1856年雅各布·纳坦松(Jakob Natanson)合成首个苯胺染料,意外开启合成药时代。
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