摘要：内侧颞叶癫痫（mesial temporal lobe epilepsy, mTLE）是局灶性癫痫的一个亚型，约三分之一患者发展为药物抵抗性癫痫，可能由包括结构改变和非编码RNA（non-coding RNA, ncRNA）失调在内的多种机制驱动。然而， 摘要：内侧颞叶癫痫（mesial temporal lobe epilepsy, mTLE）是局灶性癫痫的一个亚型，约三分之一患者发展为药 ...

The burden of cancer is grave, global, and continuing to grow. Researchers are working to develop new approaches and broaden the reach of existing modalities by bolstering traditional therapies, ...

A rapidly advancing area of biomedical innovation is shining a spotlight on miR-128-3p, a small yet powerful molecule with the potential to reshape how diseases—especially cancer—are detected, ...

EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants ...

1 Neurotrauma and Ophthalmology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK, Brmingham, UK 2 NIHR Surgical Reconstruction and Microbiology Research ...

Historically, drug discovery has centred around proteins but as targets become increasing saturated, novel RNA-targeting drugs indicate potential in rare diseases and oncology. Photo by Christoph ...

A newly revealed “aging cliff” in sperm RNA marks a conserved molecular transition from youth to later life, offering fresh insight into how a father’s age may influence the earliest stages of ...

A study led by biomedical scientists at the University of California, Riverside, has shown for the first time that a father’s exposure to microplastics (MPs) can trigger metabolic dysfunctions in his ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Scientists have uncovered how too much sunlight can flip a hidden switch inside skin cells that makes inflammation spiral out of control and increases the risk of cancer. Their research reveals that ...

Abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules that control the function of their target messenger RNAs (mRNAs). As miRNAs regulate their target genes by binding them, investigating ...