本次研究中，团队在单细胞分辨率下，对小鼠睾丸内867062 个细胞、共计 2653 个基因开展系统分析，最终成功鉴定出 26 种睾丸主要细胞类型。 解析生物体内部细胞发育、组织再生这类漫长生理过程，一直是现代生物学的一大难题。这类过程往往持续数周甚至更久 ...

Spatial omic technologies profile the molecular make-up of tissues in detail without tissue disruption, producing detailed maps with great potential for basic and applied research. Existing methods ...

Giotto Suite is a major upgrade to the Giotto package that provides tools to process, analyze and visualize spatial multi-omics data at all scales and multiple resolutions. The underlying framework is ...

All organisms growing beyond the oxygen diffusion limit critically depend on a functional vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for oxygen and ...

The liver is a highly multifunctional organ that can perform many metabolic and immunological functions due to a highly complex spatially organised microarchitecture that is disturbed in many liver ...

Taking advantages of two recent technical development, spatial transcriptomics and graph neural network, we thus introduce CCST, Cell Clustering for Spatial Transcriptomics data with graph neural ...

Spatial transcriptomics has emerged as an invaluable tool, helping to reveal molecular status within complex tissues. Nonetheless, these techniques have a crucial challenge: the absence of single-cell ...

This paper describes an important, well-organized study into an under-exploited area of spatial transcriptomics. The limitations of the approach are generally made clear, but there is insufficient ...

Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China The MOE ...