The transition of healthy arteries and cardiac valves into dense, cell-rich, calcified, and fibrotic tissues is driven by a complex interplay of both cellular and molecular mechanisms. Specific cell ...

An educational tutorial and working demonstration pipeline for RNA-seq analysis including an introduction to: cloud computing, next generation sequence file formats, reference genomes, gene annotation ...

We have created a Docker image (maayanlab/zika) packaging all the dependencies (command line tools, R and Python packages) for the pipeline, which is publically ...

单细胞测序数据天然具有高维度、强噪声、稀疏性和细胞异质性等特点，因此降维成为单细胞分析流程中不可或缺的步骤。降维的核心目标是去除冗余信息、突出生物学差异，并通过低维嵌入为聚类、可视化和后续分析如轨迹推断、细胞鉴定等提供可靠表示。

RNA sequencing (RNA-Seq) is a high-throughput sequencing approach that enables comprehensive quantification of transcriptomes at a genome-wide scale. As a result, RNA-Seq has become a routine ...

Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including ...