As the scope of proteomics is extremely broad, it is helpful to distinguish among its various aspects before discussing how microarray technology is likely to feature. Over the past decade, the ...

Definition: A microarray is a small, flat substrate carrying an ordered grid of microscopic probe features, each containing a known biological molecule, that is used to measure many molecular targets ...

Protein dot blot is an efficient immunoblotting technique enabling qualitative/semi-quantitative protein analysis without electrophoresis, relying on antigen-antibody ...

Reviewed by Dr. Tomislav Meštrović, MD, Ph.D. Microarray or biochip is a lab-oriented microscope slide that is usually made of glass, silicon chip, or nylon membrane. It is a 2D array (sometimes 3D) ...

This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...

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Background Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is ...

Background: Microarray technology has brought significant advancements to high-throughput analysis, particularly in the comprehensive study of biomolecular interactions involving proteins, peptides, ...

The term “proteome” was coined by an Australian PhD student, Marc Wilkins, in a 1994 symposium held in Siena, Italy. 2 It is a blanket term that refers to all of the proteins that an organism can ...

Protein chips are widely used for high-throughput proteomic analysis, but to date, the low sensitivity and narrow dynamic range have limited their capabilities in diagnostics and proteomics. Here we ...

Aptamers are short single-stranded DNA or RNA oligonucleotides that can bind to a wide range of target molecules with high affinity and specificity. As nucleic acids, aptamers can undergo denaturation ...