Cellular senescence, a permanent halt in cell division due to stress, spurs functional and structural changes, contributing to vascular aging characterized by endothelial dysfunction and vascular ...

Cancer is associated with reduced mitochondrial oxidative energy metabolism and naturally occurring variation in the maternally inherited mitochondrial DNA (mtDNA), which codes for critical components ...

Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being of paramount importance. This study ...

Mitochondrial respiration generates both energy (ATP) and reactive oxygen species (ROS). Insufficient energy and increased ROS from respiratory chain dysfunction may be central to the pathophysiology ...

Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, United States Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, ...

CAS Key Laboratory for Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China CAS Key ...

Reactive oxygen species (ROS) often promote acute brain injury after stroke, but their roles in the recovery phase have not been well studied. We tested the hypothesis that ROS activity mediated by ...

Due to the limitation of culturing conditions (Nichols et al., 2010; Zhang et al., 2018c) or the characteristics like slow growth (Vartoukian et al., 2010), most microbial species comprising ...

In ischemic stroke, breakdown of the blood-brain barrier (BBB) aggravates brain damage. Endothelial detachment contributes to BBB disruption and neurovascular dysfunction, but its regulation in stroke ...