Anthropic brings Mythos to the masses with Claude Fable 5, its most powerful generally ...

Anthropic is pricing both Fable 5 and Mythos 5 at $10 per million input tokens and $50 per million output tokens. The company says that is less than half the price of Claude Mythos Preview ...
IEEE

On Monomeric and Multimeric Structures-Based Protein-Ligand Interactions

Abstract: Many ligands simultaneously interact with multiple protein chains in quaternary structure (QS). However, a significant number of previous studies on template-based modeling of protein-ligand ...
GitHub

ProLLaMA: A Protein Language Model for Multi-Task Protein Language Processing

Our ProLLaMA is the first model to our knowledge capable of simultaneously handling multiple PLP tasks, including generating proteins with specified functions based on the user's intent. EPGF is a ...
eLife

Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

The authors report how a previously published method, ReplicaDock, can be used to improve predictions from AlphaFold-multimer (AFm) for protein docking studies. The level of improvement is modest for ...
Front Line Genomics

AI Models For Protein Structure Prediction

Understanding how amino acid sequences translate into complex, three-dimensional structures is a problem that has been puzzling scientists for decades 1. Unlocking this mystery is key to uncovering ...
eLife

Protein language model-embedded geometric graphs power inter-protein contact prediction

This study presents a useful deep learning-based inter-protein contact prediction method named PLMGraph-Inter which combines protein language models and geometric graphs. The evidence supporting the ...
C&EN

MSF-PFP: A Novel Multisource Feature Fusion Model for Protein Function Prediction

Key Laboratory of Signal Detection and Processing in Xinjiang Uygur Autonomous Region, Xinjiang University, Urumqi 830046, China Key Laboratory of Software Engineering, Xinjiang University, Urumqi ...
Frontiers

Before and after AlphaFold2: An overview of protein structure prediction

Three-dimensional protein structure is directly correlated with its function and its determination is critical to understanding biological processes and addressing human health and life science ...
Frontiers

Improving peptide-protein docking with AlphaFold-Multimer using forced sampling

Protein interactions are key in vital biological processes. In many cases, particularly in regulation, this interaction is between a protein and a shorter peptide fragment. Such peptides are often ...
GitHub

The MULTICOM protein structure system.

This repository include the source code and documents of both template-based and template-free modeling of the MULTICOM protein structure prediction system. 1D feature prediction, contact prediction, ...
Nature

Protein design and variant prediction using autoregressive generative models

The ability to design functional sequences and predict effects of variation is central to protein engineering and biotherapeutics. State-of-art computational methods rely on models that leverage ...