All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.

Fantasy football rankings 2025: Breakouts, sleepers, busts from model which nailed C.J. Stroud's tough season SportsLine simulated the new NFL season 10,000 times to help form your 2025 Fantasy ...