Background Wolf–Hirschhorn syndrome (WHS) is a contiguous gene deletion syndrome involving variable size deletions of the 4p16.3 region. Seizures are frequently, but not always, associated with WHS.

Figure 1: RNA-seq data uses short reads of mRNA which is free of intronic non-coding DNA. These reads must then be aligned back to the reference genome. Credit: Technology Networks. Early RNA-seq ...

Copyright: © 2026 The Author(s). Published by Elsevier B.V. We analysed two independent target cohorts: a case–control cohort including people with a confirmed ...

Imagine you're a detective, but instead of solving crimes, you're uncovering the secrets hidden within our genes. Every cell in your body is constantly "talking" through gene expression, and ...

Background: Microarray technology has brought significant advancements to high-throughput analysis, particularly in the comprehensive study of biomolecular interactions involving proteins, peptides, ...

MA plots visualize the relationship between log2 fold change (M values) and mean of normalized counts (A values) for differential expression analysis results. First introduced for microarray ...

Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by CMA alone, including two likely de ...

Abstract: There are more than 10 million new cases of Alzheimer's patients worldwide each year, which means there is a new case every 3.2 s. Alzheimer's disease (AD) is a progressive neurodegenerative ...

The term “proteome” was coined by an Australian PhD student, Marc Wilkins, in a 1994 symposium held in Siena, Italy. 2 It is a blanket term that refers to all of the proteins that an organism can ...

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing 102206, China ...

Microarrays are a two-dimensional arrangement of biological samples, with samples placed in spots numbering in the thousands and organized into columns and rows. They allow for efficient analysis of ...