Abstract: As the least understood mode of alternative splicing, Intron Retention (IR) is emerging as an interesting area and has attracted more and more attention in the field of gene regulation and ...

Bacteria encode a variety of reverse transcriptases (RTs) that evolved from mobile group II intron RTs to perform different cellular functions. A previous study found that one such domesticated group ...

The ability to target and regulate RNA function with small molecules has vast potential, but molecular understanding of the metrics governing RNA–drug interactions is limited. Here, we present a ...

O-GlcNAcylation is the reversible post-translational addition of β-N-acetylglucosamine to serine and threonine residues of nuclear and cytoplasmic proteins. It plays an important role in several ...

Voice recognition is getting integrated in nearly all facets of modern living, but there remains a big gap: Speakers of minority languages and those with thick accents or speech disorders like ...

Intron Health has trained its algorithms with data sets from clinicians across Africa to boost the accuracy of spoken medical terms, which a larger, more general-purpose platform would have struggled ...

Alternative splicing (AS) is a widespread mechanism in eukaryotic gene regulation that enables the generation of multiple protein isoforms from a single gene. AS can result in the inclusion or ...

One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are segments of noncoding DNA that must be removed from the genetic code ...

Researchers have reported a fundamentally new approach to the structural investigation of RNA molecules. ROCK, as it is called, uses an RNA nanotechnological technique that allows it to assemble ...

Human epidermal growth factor receptors (HER/ERBB) form dimers that promote cell proliferation, migration, and differentiation, but overexpression of HER proteins results in cancer. Consequently, ...