The structure of a large nucleic acid complex formed by the 10–23 DNA enzyme bound to an RNA substrate was determined by X–ray diffraction at 3.0 Å resolution. The 82–nucleotide complex contains two ...

Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, ...

This study advances our understanding of the allosteric regulation of anaerobic ribonucleotide reductases (RNRs) by nucleotides, providing valuable new structural insight into class III RNRs ...

Truvada (emtricitabine/tenofovir disoproxil fumarate) and Descovy (emtricitabine/tenofovir alafenamide) are brand-name oral tablets. They’re both approved to treat and prevent HIV. Only Truvada is ...

Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that ...

Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease.

Uncoupling protein 1 (UCP1) is a mitochondrial carrier protein responsible for thermogenesis in brown adipose tissue, and a putative therapeutic target for the treatment of obesity and related ...

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There is compelling evidence showing that the structurally complex pectic polysaccharide rhamnogalacturonan II (RG-II) exists in the primary cell wall as a borate cross-linked dimer and that this ...