Intervertebral disc degeneration (IDD) is a leading cause of spinal disorders worldwide. Current clinical therapies for IDD are often constrained by limited efficacy, notable adverse effects, and high ...

This work demonstrates the therapeutic potential of recombinant human PDGF-AB/BB proteins in alleviating the senescent signatures of primary human intervertebral disc cells. The study represents a ...

Flow Chemistry Group, Van’t Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), Amsterdam 1098 XH, The Netherlands ...

Key Laboratory of Roads and Railway Engineering Safety Control (Shijiazhuang Tiedao University), Ministry of Education, Shijiazhuang 050043, China ...

Understanding the link between genetic and environmental influences on the development of metabolic syndrome is crucial to developing better therapies for treatment and prevention. While studies have ...

Inflammatory arthritis (IA) is characterized by dysregulation of immune cells that leads to joint swelling, pain, and tissue breakdown. Therefore, understanding the mechanisms underlying this ...

The Factor O2 VAM has certainly cemented itself as one of the lightest disc road race bikes on the market, and it rides as well as you would imagine. As an owner of the previous generation O2, I was ...

Intervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder and is recognized as a major contributor to discogenic lower back pain. However, the molecular mechanisms ...

Doesn’t have the same wow factor as some of Factor’s previous bikes; doesn’t come cheap The Factor Ostro VAM is an all-round road bike that's intended to strike an ideal balance between aerodynamic ...

Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the ...

It’s a bike that I’ve been keen to test ever since the original Factor O2 burst onto the scene under the AG2R La Mondiale pro team in 2016. But somehow it never happened. I have hardly even seen one ...

This is not the first Eddy Merckx 525 I have tested. Some years back I reviewed the EMX-525, which was similar in both look and name, but came equipped with rim brakes. But make no mistake, this isn’t ...