This important study presents evidence to support the efficacy of oral administration of DNL343, an integrated stress response (ISR) suppressor, in two mouse models in which neurodegeneration is ...

This study presents solid evidence to support the effectiveness of the novel eIF2B activator DNL343 in mitigating the integrated stress response (ISR) and reducing neurodegeneration associated with ...

Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish.

Muscle synergy is regarded as a motor control strategy deployed by the central nervous system (CNS). Clarifying the modulation of muscle synergies under different strength training modes is important ...

Widespread transduction of the CNS with a single, non-invasive systemic injection of adeno-associated virus is now possible due to the creation of blood-brain barrier-permeable capsids. However, as ...

Multilayer network clustering is used in such diverse areas as optimal islanding of critical infrastructures, analysis of trade agreements, and monitoring ecological interaction patterns. We propose a ...

Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, and Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science ...

The advent of big data era has imposed both running time and learning efficiency challenges for the machine learning researchers. Biomedical OMIC research is one of these big data areas and has ...

The RAID-6 specification calls for a storage system with multiple storage devices to tolerate the failure of any two devices. Numerous erasure coding techniques have been developed that can implement ...

The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is ...