Codon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant ...

aDepartment of Biomedical Informatics, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China bDivision of Life ...

Rotavirus A (RVA) infects a relatively wide host range. Studying the evolutionary dynamics of viral genomes and the evolution of host adaptations can inform the development of epidemiological models ...

Synonymous recoding of viral genomes by codon-pair deoptimization (CPD) provides live-attenuated vaccine candidates expected to be genetically stable. However, their actual genetic stability is ...

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Although respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants, a safe and effective vaccine is not yet available. Live-attenuated vaccines (LAVs) are ...

Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus ...

Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps ...

Human parainfluenza virus type 3 (HPIV3) is an important viral agent of severe respiratory infection in young children worldwide and lacks an approved vaccine. We describe the development of ...