Despite the limited research on the effects of altitude (or hypoxic) training interventions on team-sport performance, players from all around the world engaged in these sports are now using altitude ...

Edited by William Kaelin Jr., Dana-Farber Cancer Institute Department of Medical Oncology, Boston, MA; received January 23, 2025; accepted July 18, 2025 ...

Heme is essential for aerobic life. Heme is synthesized in mitochondria, but the mechanisms that control how heme moves around in cells, and how this connects to the wider aspects of cellular function ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Data-driven ...

Discovering the rules of synaptic plasticity is an important step for understanding brain learning. Existing plasticity models are either (1) top-down and interpretable, but not flexible enough to ...

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 ...

The HIF oxygen sensing pathway. Under normoxic conditions, proline (P) and asparaginyl (N) residues in HIFαs are first recognized and degraded by activated prolyl hydroxylases (PHDs) and asparaginyl ...

We introduce for the first time a new product line able to make high accuracy measurements of a number of water chemistry parameters in situ: i.e., submerged in the environment including in the deep ...

An expanded Methods section is available in the Online Data Supplement. The authors declare that all supporting data are available within the article (and its in the Online Data Supplement).

Vascular occlusion and complex plexiform lesions are hallmarks of the pathology of severe pulmonary arterial hypertension (PAH) in patients. However, the mechanisms of obliterative vascular remodeling ...