Blood vessels form the first organ in the developing embryo and build extensive networks that supply all cells with nutrients and oxygen throughout life. As blood vessels get older, they often become ...

Background Anti-vascular endothelial growth factor (VEGF) therapies are central to the treatment of advanced hepatocellular carcinoma (HCC), yet clinical benefit is often limited by adaptive ...

Metabolic reprogramming and epigenetic modification have been widely observed in cancer research. Based on accumulating experimental evidence in recent years, beginning with metabolic reprogramming ...

Trained immunity presents a unique target for modulating the immune response against infectious and non-infectious threats to human health. To address the unmet need for training-targeted therapies, ...

Tumor endothelial cells (TECs), like tumor cells, adopt embryonic-like traits to evade immune detection and facilitate tumor growth. Our research systematically identified embryo-specific features to ...

fUniversité Paris Cité et Université Sorbonne Paris Nord, Inserm, INRAE, Centre de Recherche en Épidémiologie et Statistiques, Paris, France gUniversity of Rennes, Inserm, Ecole des Hautes Etudes en ...

Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew as well as differentiate into different cancer cell lineages. The exact mechanisms by which cancer stem ...

The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and ...

Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases. Here we studied how disseminated tumor cells sense ...

Materials Science & Engineering, Stanford University, Stanford, California 94305, United States Bioengineering, Stanford University, Stanford, California 94305, United States Pediatric Endocrinology, ...