基于上述理由，羟氯喹的日剂量根据实际体重计算，每日最多 5 mg/kg，且不超过400 mg。有条件检测羟氯喹的血药浓度，则尽量控制在 500~2000 ng/mL[9]；但需注意每日使用羟氯喹 3~6 个月后的血药浓度最准确。每年可检查 1~2 次 ...

长期以来，尽管遗传因素在SLE的发病中的重要作用已是共识，但其确切作用始终未得到揭示。近年来，数个遗传学研究表明单基因突变即可导致SLE，单基因狼疮的概念呼之欲出。然而临床上数量庞大的SLE患者得到明确遗传学解释的仍然是少数，这提示SLE发病的遗传基础仍然有待进一步研究。

Merck’s lupus drug enpatoran has failed to meet the primary endpoint in a subgroup of patients, but the drug's development is ...

Despite advancements in the management of systemic lupus erythematosus (SLE), patients experience poor health-related quality of life (hrQoL) and premature death due to disease severity and treatment ...

For patients with systemic lupus erythematosus (SLE) and pericarditis, recurrence of pericarditis occurs in more than 20% of patients and associated factors include younger age, prednisone treatment, ...

Uniklinikum Erlangen at Friedrich-Alexander-Universität Erlangen-Nürnberg has successfully treated more than 45 people with autoimmune diseases using ...

Systemic lupus erythematosus (SLE) is a complex, chronic, autoimmune disorder that involves multiple organ systems including the skin, joints, heart, lungs, blood, kidneys and, in the most severe ...

Recurrent pericarditis occurs in one fifth of patients with systemic lupus erythematosus, with higher rates being observed in younger patients and those receiving oral prednisone therapy.

Patients with SLE vs individuals without autoimmune disease demonstrated higher rates of peripartum complications.

Help us make Medscape the best clinical resource possible. Please use this form to submit your questions or comments on how to make this resource center more useful to clinicians.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, in which neuropsychiatric manifestations are a common cause of significant morbidity. The American College of Rheumatology ...

Factors associated with recurrence of pericarditis include younger age, prednisone treatment, active systemic lupus erythematosus, and time since initial episode.