Methods In this international, randomized trial, we assigned critically ill adults who were undergoing invasive ventilation to receive intravenous pantoprazole (at a dose of 40 mg daily) or matching ...

The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient level ...

Approaches to early detection of cancer often seem contentious, but the big-picture view is actually one of remarkable consensus. All major guideline groups recommend the Papanicolaou smear, ...

Methods In this phase 3 trial, we randomly assigned patients with resectable, macroscopic stage III melanoma to two cycles of neoadjuvant ipilimumab plus nivolumab followed by surgery or surgery ...

Artificial Intelligence has tremendous potential to advance clinical practice and the delivery of patient care.

Despite high cancer-related mortality, health systems serving American Indian and Alaska Native populations offer only primary care. The University of Oklahoma is bridging the gap with oncology ser ...

In patients with STEMI with cardiogenic shock, early mechanical support with a microaxial pump reduced the risk of death at 180 days, with the survival benefit persisting up to 10 years despite dev ...

The author describes the implementation of a clinical-care program involving pronuclear transfer to minimize the transmission of mitochondrial disease. He also describes the long pathway leading to a ...