Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024). Androgen receptor (AR) is ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

Facundo D. Batista (Chief Editor) Facundo is the Phillip T. and Susan M. Ragon Professor of Microbiology and Immunology at Harvard Medical School, and Associate Director of the Ragon Institute of MGH, ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

De novo protein design is of fundamental interest to synthetic biology, with a plethora of computational methods of various degrees of generality developed in recent years. Here, we introduce ...

Fungal infections and autoimmunity share a complex, bidirectional relationship that significantly impacts patient outcomes. Emerging evidence highlights how fungal pathogens contribute to autoimmune ...

Our study shows that TP53 mutations in AML cells lead to increased resistance to CAR T-cells in vitro. CAR T-cells co-incubated with target TP53 -mutant AML blasts exhibited decreased proliferation ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...