Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X‐ray crystallography we have ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The transcriptional regulators TAZ and YAP ...

The isolation of pad4‐2 as a suppressor of RPP5 ‐mediated resistance in Ler as well as the requirement for PAD4 in RPP2 and RPP4 resistance in Col‐0 shows that PAD4 participates in several EDS1 ...

A proteolytically inactive BACE1 knock-in (BACE1-KI, D289N) is compared with a BACE1 knockout (BACE1-KO) mouse to dissect ...

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In E. coli, the Cascade complex alone is able to generate crRNA but requires Cas3 to achieve immunity against foreign DNA (Brouns et al, 2008). Hence, Cas3 appears to be a key protein of CRISPR system ...

NINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro ...

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Keap1 is a BTB‐Kelch substrate adaptor protein that regulates steady‐state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch ...

Both microtubule-binding protein tau and RNA-binding protein TDP-43 have been associated with neurodegenerative diseases, such as Alzheimer’s disease, including in co-pathological deposition with each ...

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...

Plants have evolved a multi‐layered system of defence responses that can be activated upon recognition of invading pathogens. One layer includes transmembrane receptors that recognize evolutionarily ...