DRP1 is a dynamin-related large GTPase responsible for mitochondrial fission, which ensures proper mitochondrial distribution, morphology and quality control. Despite its relevance, the mechanism of ...

Defects in proteostasis and protein aggregation are hallmarks of aging and neurodegenerative diseases. Mitochondria have evolved a specialized unfolded protein response (UPR mt) to maintain ...

Most of these can be installed via conda packages. Noting that some tools have different samtools version expectations, which can lead to problems. In particular the bioconda install of samtools is v0 ...

Populations of cells can be perturbed by various chemical and genetic treatments and the impact on the cells’ gene expression (transcription, i.e. mRNA levels) and morphology (in an image-based assay) ...

Eberhardt et al., 2021 ). The proteins were transformed into a macromolecular format, and the molecular docking was performed with the ligands, using specific grid box parameters (Table 2). For ...