The discovery of catalytic RNA transformed our understanding of life’s beginnings. Clare Sansom explores how the RNA world hypothesis bridges the gap between non-living chemistry and the first cells ...

Secondary-structure-informed RNA Inverse Design, or simply structure-informed-RNA-inverse-design, is a geometric deep learning pipeline for 3D RNA inverse design that also incorporates RNA ...

Prebiotically plausible nonenzymatic aminoacylation of RNA has been an elusive but key requirement for studying the origin of translation. Here, we show that even inefficient, chemical RNA ...

python 3 >= 3.9; pandas == 1.5; numpy == 1.23; scikit-learn == 1.1.3; xgboost == 1.7.1; imbalanced-learn == 0.9.1; biopython >= 1.79; tqdm >= 4.64 ViennaRNA (Optional ...

The 3D architectures of RNAs are essential for understanding their cellular functions. While an accurate scoring function based on the statistics of known RNA structures is a key component for ...

The term ‘RNA-seq’ refers to a collection of assays based on sequencing experiments that involve quantifying RNA species from bulk tissue, single cells or single nuclei. The kallisto, bustools and ...

Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta ...

Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human ...