Background Wolf–Hirschhorn syndrome (WHS) is a contiguous gene deletion syndrome involving variable size deletions of the 4p16.3 region. Seizures are frequently, but not always, associated with WHS.

Figure 1: RNA-seq data uses short reads of mRNA which is free of intronic non-coding DNA. These reads must then be aligned back to the reference genome. Credit: Technology Networks. Early RNA-seq ...

Copyright: © 2026 The Author(s). Published by Elsevier B.V. We analysed two independent target cohorts: a case–control cohort including people with a confirmed ...

Background: Microarray technology has brought significant advancements to high-throughput analysis, particularly in the comprehensive study of biomolecular interactions involving proteins, peptides, ...

Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by CMA alone, including two likely de ...

Abstract: There are more than 10 million new cases of Alzheimer's patients worldwide each year, which means there is a new case every 3.2 s. Alzheimer's disease (AD) is a progressive neurodegenerative ...

The term “proteome” was coined by an Australian PhD student, Marc Wilkins, in a 1994 symposium held in Siena, Italy. 2 It is a blanket term that refers to all of the proteins that an organism can ...

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing 102206, China ...

Microarrays are a two-dimensional arrangement of biological samples, with samples placed in spots numbering in the thousands and organized into columns and rows. They allow for efficient analysis of ...