In the food-borne pathogen Listeria monocytogenes, virulence genes are expressed at 37°C, but not 30°C. This process is under the control of PrfA — a transcriptional activator thermoregulated by a ...

李斯特菌prfA转录因子靶向抑制研究：通过计算对接和分子动力学模拟评估蜂胶化合物的抑制活性，发现其与prfA结合稳定且自由能低，为抑制李斯特菌致病性提供新策略。 摘要 单核细胞增生李斯特菌是全球恶性李斯特菌病的致病菌，由于耐药性的出现和死亡率的 ...

编辑推荐：本研究针对李斯特菌毒力调控关键因子PrfA的抑制机制不明问题，通过结构生物学手段解析了环境寡肽以序列非依赖方式竞争性占据GSH结合位点的分子机制，发现β折叠样相互作用介导的混杂性结合模式及疏水残基选择性识别特征，为病原菌环境适应与 ...

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Pull requests help you collaborate on code with other people. As pull requests are created, they’ll appear here in a searchable and filterable list. To get started, you should create a pull request.

JavaScript frameworks play a crucial role in today’s web application developments as they help developers build effective, flexible, and best web applications. These frameworks make otherwise ...

A graph node engine and editor written in Javascript similar to PD or UDK Blueprints, comes with its own editor in HTML5 Canvas2D. The engine can run client side or server side using Node. It allows ...

Abstract: This paper aims to use an experimental approach to determine the best performing and most stable web programming languages for building a website. Through a comprehensive comparison of ...

Learn about the best practices for web development and JavaScript programming, complete with code examples and real-world scenarios. JavaScript is a versatile and widely used programming language that ...

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