The fetus is an allograft onto the mother and is at risk of rejection, so there is a strong T helper 2 (T H 2)-cell bias to fetal innate immune responses, a tendency also initially manifest in the ...

Innate immunity has a critical role in the early stage of the host defense response by the timely recognition of pathogenic or danger signals by various cell surface or cytoplasmic receptors. This is ...

Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for ...

Every organism must recognize damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs) to react rapidly. The immune system requires potent negative regulators to control ...

Although an arsenal of antimicrobial mechanisms is deployed to kill bacteria in infected cells, pathogens have learnt how to manipulate host defence mechanisms to survive and eventually replicate.

In the previous article, I introduced antibodies. Antibodies can bind to pathogens and mark them as 'the enemy'. However, in reality, antibodies themselves cannot eat or directly destroy pathogens. So ...

Louse-borne relapsing fever is caused by the spirochete bacterium Borrelia recurrentis, which is transmitted by body lice (not head lice). The disease was first described by Hippocrates (460–370 B.C.) ...

Sanofi (NASDAQ:SNY) said on Wednesday that it has decided to discontinue the phase 3 MOBILIZE trial evaluating riliprubart in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who ...

Priority review for cemdisiran addresses adult anti-AChR–positive gMG, leveraging a priority review voucher and aligning US and EU regulatory timelines through 2027. RNAi-mediated C5 suppression ...

InflaRx intends to engage with EMA regarding both vilobelimab and izicopan to evaluate the regulatory path to approval in ANCA-associated vasculitis (AAV) The Company is assessing the most efficient ...