A link between oxidative stress and hypertension has been firmly established in multiple animal models of hypertension but remains elusive in humans. While initial studies focused on inactivation of ...

The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme ...

Division of Pediatric Surgery, Department of Surgery, Texas Children’s Hospital and Baylor College of Medicine, Feigin Center at Texas Children’s Hospital, 1102 Bates Ave, C.450.05, Houston, Texas ...

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 ...

The HIF oxygen sensing pathway. Under normoxic conditions, proline (P) and asparaginyl (N) residues in HIFαs are first recognized and degraded by activated prolyl hydroxylases (PHDs) and asparaginyl ...

We introduce for the first time a new product line able to make high accuracy measurements of a number of water chemistry parameters in situ: i.e., submerged in the environment including in the deep ...

Intracellular sensors of essential metals are upstream homeostatic responders that detect changes in metal levels to initiate protective responses. But, unlike other metals, a mammalian manganese (Mn) ...

Edited by John T. Groves, Princeton University, Princeton, NJ, and approved November 19, 2020 (received for review August 6, 2020) Here, we demonstrate that Rev-Erbβ contains Fe 3+-heme yet still ...

Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O 2) delivery. Sphingosine 1-phosphate (S1P)—a highly enriched biolipid ...

Portland cement is an essential ingredient for the construction industry, used to make concrete and mortar. There are more than 2,000 active cement plants around the world producing over 3.5 billion ...