pggb builds pangenome variation graphs from a set of input sequences. A pangenome variation graph is a kind of generic multiple sequence alignment. It lets us understand any kind of sequence variation ...

Organellar genomes of plants are semi-autonomous genetic systems housed within chloroplasts and mitochondria and provide key data in deciphering the plant tree of life, adaptive evolution, and ...

Global, regional, and country/territory-level data on key dimensions of human development, with interactive insights and publications. The human development data are globally comparable, linked to the ...

Many biological networks are modeled with multivariate discrete dynamical systems. Current theory suggests that the network of interactions captures salient features of system dynamics, but it misses ...

There are three key aspects to genetic disease associations: comprehensive variant discovery, accurate allele-frequency determination, and an understanding of the pattern of normal variation and its ...

For small genomes, it is possible to study genetic variation by assembling whole genomes and then comparing them via whole-genome comparison 6,7. For large genomes, such as the human genome, complete ...

Deep sequencing has enabled the investigation of a wide range of environmental microbial ecosystems, but the high memory requirements for de novo assembly of short-read shotgun sequencing data from ...