Kidney transplantation remains the most effective treatment for end-stage kidney disease. Still, the development of de novo donor-specific antibodies (dnDSA) increases the risk of rejection and ...

A key strategy to increase the sustainability and productivity of livestock production is to modulate ruminant microbiota to produce absorbable nutrients rather than the potent greenhouse gas methane.

In the context of in silico clinical trials, mechanistic computer models for pathophysiology and pharmacology (here Quantitative Systems Pharmacology models, QSP) can greatly support the decision ...

Patients with atrial fibrillation and severe chronic kidney disease have higher risks of bleeding, thromboembolism, and mortality. However, optimal anticoagulant choice in these high‐risk patients ...

cWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK ...

The morbidity and mortality rates of patients with heart failure (HF) and functional mitral regurgitation (MR) remain substantial despite guideline-directed medical therapy for HF. We evaluated the ...

aDiscipline of Biomedical Informatics and Digital Health, Faculty of Medicine and Health, University of Sydney, NSW, Australia bSchool of Population and Global Health, Faculty of Health and Medicine, ...

A Clinical-Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts Using retrospective data from ...

Atrial fibrillation is a chronic, progressive disorder, and persistent forms of atrial fibrillation are associated with increased risks of thromboembolism and heart failure. Catheter ablation as ...

Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, a class of compounds that stimulate endogenous erythropoietin production. We conducted two randomized, open-label, ...

As anthropogenic impacts to Earth systems accelerate, biodiversity knowledge integration is urgently required to support responses to underpin a sustainable future. Consolidating information from ...