EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants ...

An Italy that can’t grow its own wheat for pasta? It’s a race against time. Using a shared database in a Microsoft super-computer, scientists from Italy and other countries are working together to ...

Update: See bonito branch for improved performance and experiments using bonito basecalling and other improvements. First, generate a list of read ids to decode using the script util/generate_read_ids ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Gout is an inflammatory joint disease caused by abnormal uric acid metabolism, characterized by the deposition of urate crystals in joints and surrounding tissues, leading to acute or chronic ...

In this issue, Zhai et al. (1) report a “DNA language model” designed to help identify the most critical variants in DNA sequence. With only a four-letter alphabet (A, C, G, and T), most base pairs in ...

The puzzle seems impossible: take a three-billion-letter code and predict what happens if you swap a single letter. The code we’re talking about—the human genome—stores most of its instructions in ...

In a big leap for genomics, Google on Wednesday unveiled a powerful AI model that predicts how single DNA mutations affect the complex machinery regulating gene activity. Named AlphaGenome, the tool ...

Abstract: For DNA data storage to become a feasible technology, all aspects of the encoding and decoding pipeline must be optimized. Writing the data into DNA, which is known as DNA synthesis, is ...

Researchers from the Henry and Marilyn Taub Faculty of Computer Science have developed an AI-based method that accelerates DNA-based data retrieval by three orders of magnitude while significantly ...