This Research Topic is the second volume of "The Role of Complement in Health and Disease" Community Series. Please see volume I here. The complement system is a crucial mediator of the innate immune ...

The human complement system has a pivotal role in the recognition, opsonization and elimination of microbial intruders. This functionality is maintained by a well-balanced interaction network of serum ...

Kaposi's sarcoma associated herpesvirus (KSHV) establishes persistent infection in its host and is associated with the development of Kaposi's sarcoma, as well as several lymphoproliferative disorders ...

Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for ...

Antibodies, also known as immunoglobulins (IGs), are glycoproteins produced in response to an immune reaction and exhibit high specificity for the antigens that elicit the response. An antibody ...

Changes to pathogens’ ability to infect particular hosts (“host tropism”) often dictate modern infectious disease outbreaks. Lyme disease bacteria present a suitable model to study the molecular ...

Inflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory ...

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