New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

Compared with Levenberg Marquardt, the local and initial value sensitive algorithm, Simplex, a global algorithm, is the only robust and easy method which is irrelevant to initial input value.

New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

The mission to improve the widely used simplex-method algorithm showed instead why it works so well.

Dongliang Liu, Peng Zheng, Jianghao Wu, Haotian Yin, Linna Zhang, A new method for cylindricity error evaluation based on increment-simplex algorithm, Science ...

OXFORD, England, April 18, 2025--A new paper, released this week on bioRxiv, introduces hifiasm-ONT, a breakthrough genome assembly algorithm that enables partially phased, near telomere-to-telomere ...

Furthermore, the computational complexity of the policy-iteration and simplex methods is superior to that of the only known strongly polynomialtime interior-point algorithm [Ye, Y. 2005.