Voltage-gated sodium channels (VGSCs) are responsible for transmembrane (TM) sodium ion conduction and, in eukaryotes, for electrical signalling in excitable cells 1. In humans, mutations in different ...

However, such functional leaps by combination of unrelated domains have not been directly demonstrated. Here we show that highly specific and complex protein functions can be generated by joining a ...

Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their ...