研究揭示了整合素配体MAdCAM-1通过其Mucin-like结构域与细胞膜微环境负电荷之间的静电斥力调控整合素α4β7介导的细胞黏附的新机制，为精确调控免疫细胞向淋巴组织或炎症部位的迁移提供了新的思路。 免疫细胞的黏附与迁移是机体免疫与宿主防御的关键环节。

研究揭示了细胞膜负电荷与黏膜地址素细胞黏附分子-1（Mucosal Addressin Cell Adhesion Molecule-1，MAdCAM-1）之间的静电斥力调控MAdCAM-1与整合素α4β7黏附的新机制。 免疫细胞的黏附及迁移是机体免疫与宿主防御的关键环节，免疫细胞表面的整合素、内皮细胞表面的配体 ...

Response to immune checkpoint inhibitor (ICI) rechallenge in patients with metastatic renal cell carcinoma who progressed on prior ICI: A systematic review and meta-analysis. Biomarkers of response to ...

Correlation between CARINH expression and clinical outcomes in metastatic clear-cell renal cell carcinoma (mccRCC). Association of KIM-1–MAdCAM-1 composite score quartiles with progression-free and ...

Please provide your email address to receive an email when new articles are posted on . An investigational anti-MAdCAM antibody was safe, well tolerated and superior to placebo for inducing remission ...

U.S. FDA Grants Shire Orphan Drug Designation for Investigational Anti-MAdCAM Antibody SHP647 for the Treatment of Moderately to Severely Active Ulcerative Colitis in Pediatric Patients Cambridge, Ma.