研究揭示了整合素配体MAdCAM-1通过其Mucin-like结构域与细胞膜微环境负电荷之间的静电斥力调控整合素α4β7介导的细胞黏附的新机制，为精确调控免疫细胞向淋巴组织或炎症部位的迁移提供了新的思路。 免疫细胞的黏附与迁移是机体免疫与宿主防御的关键环节。

我们知道，癌症患者因为免疫力低通常更容易感染，使用广谱抗生素也是挺常见的事，但抗生素的使用会改变肠道微生物的组成，肠道菌群失调又会影响免疫检查点抑制剂（ICB）的治疗效果。 近年来，不少研究显示，在ICB治疗前1个月或1年接受抗生素治疗，与 ...

研究揭示了细胞膜负电荷与黏膜地址素细胞黏附分子-1（Mucosal Addressin Cell Adhesion Molecule-1，MAdCAM-1）之间的静电斥力调控MAdCAM-1与整合素α4β7黏附的新机制。 免疫细胞的黏附及迁移是机体免疫与宿主防御的关键环节，免疫细胞表面的整合素、内皮细胞表面的配体 ...

Correlation between CARINH expression and clinical outcomes in metastatic clear-cell renal cell carcinoma (mccRCC). Association of KIM-1–MAdCAM-1 composite score quartiles with progression-free and ...

U.S. FDA Grants Shire Orphan Drug Designation for Investigational Anti-MAdCAM Antibody SHP647 for the Treatment of Moderately to Severely Active Ulcerative Colitis in Pediatric Patients Cambridge, Ma.

Please provide your email address to receive an email when new articles are posted on . An investigational anti-MAdCAM antibody was safe, well tolerated and superior to placebo for inducing remission ...