Solid lipid nanoparticles (SLNs) are submicron colloidal carriers formed from physiological lipids that remain solid at ambient and body temperatures. They combine the biocompatibility and ...

Lipid nanoparticle delivery systems encompass a range of colloidal carriers—including liposomes, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)—designed to encapsulate and ...

The earliest iteration of LNPs was the development of liposomes in the 1960s, with the first liposome-based drug product, Doxil, receiving FDA approval in 1995. In the early 1990s, a second generation ...

Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including ...

A review maps high throughput strategies that link automation, microfluidics, and barcoding into a unified pipeline, enabling faster, more predictive lipid nanoparticle development for genetic ...

Encapsulating an active substance in a liposome or lipid nanoparticle can minimize cytotoxicity and increase blood circulation by bypassing the immune system. Several techniques can improve a drug's ...

Nanotechnology is reshaping dermatology by improving drug delivery, photoprotection, barrier repair, follicular targeting, and antimicrobial activity across conditions such as acne, psoriasis, atopic ...

Lipid-based nanoparticles (LNPs) are becoming an essential platform in pharmaceutical research and manufacturing. They’re used to improve the delivery of mRNA, enhance the absorption of poorly ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

A new study shows that lipid nanoparticles restructure their membrane significantly after being absorbed into a cell and ending up in an acidic environment. (Nanowerk News) Vaccines and other ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

The rapid clinical validation of mRNA technology during the COVID‑19 pandemic has powerfully accelerated its application in ...