研究人员发现了一个巨大的癌症特异性RNA网络，该网络定义了肿瘤的特性，并在某些情况下积极驱动疾病。这项研究始于T3p，一种在乳腺癌中检测到但在正常组织中未检测到的小RNA分子。当它在2018年首次被描述时，它显得与众不同。最初的发现启动了一项为期六年的努力，旨在系统地识别主要癌症类型中类似的孤儿非编码RNA（oncRNA），确定哪些oncRNA积极地促进疾病发展，并测试它们是否可以通过简单的血液测 ...

A mysterious RNA found in breast cancer led scientists to uncover an entire hidden class of cancer-specific RNAs across ...

One of the greatest mysteries of our planet is how a soup of lifeless chemicals transformed into the first living cell. There are several competing theories about where this happened, from frozen ...

Researchers at the MRC Laboratory of Molecular Biology in Cambridge have discovered a ribozyme that is shockingly small, yet ...

People with weakened immune systems are at constant risk of infection. Pseudomonas aeruginosa, a common environmental bacterium, can colonize different body parts, such as the lungs, leading to ...

Researchers have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections. Their research findings can inform the development of future treatments for ...

With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology ...

These random molecules were fed a collection of three-base-long RNAs, each linked to a chemical tag. The idea was that if a molecule is capable of ligating one of these short RNA fragments to itself, ...

Small, biologically inert molecules can be converted into bioactive degraders that selectively downregulate disease-causing RNAs. By attaching an RNA molecular recognition element to a second compound ...

Neurons have a "hibernation mode." Scientists discover how brain cells use RNA tentacles to lock their protein factories together to survive when energy is low.