For patients with moderate-to-severe plaque psoriasis, the interleukin-23-receptor antagonist peptide JNJ-77242113 shows greater efficacy than placebo, according to a study published in the Feb. 8 ...

The use of monoclonal antibodies has changed the treatment of several immune-mediated inflammatory diseases, including psoriasis. However, these large proteins must be administered by injection.

In a previous study, it has been shown that the population of Th17 lymphocytes was increased in patients with FMF. IL-21 and IL-23 play significant roles in the production and differentiation of Th17 ...

IL-23R is a heterodimeric receptor composed of the IL-23R subunit in complex with IL-12Rβ1 [1]. IL-23R is classically found on the surface of T cells, where it is activated by its ligand cytokine, ...

In a trial involving 255 patients with moderate-to-severe plaque psoriasis, the oral interleukin-23–receptor antagonist peptide JNJ-77242113 showed a dose–response relationship and greater efficacy ...

Researchers determine the clinical and demographic risk factors of paradoxical eczema as well as the overall incidence and biologic-class-specific risk factors and incidence of paradoxical eczema in ...