Heme, an iron–protoporphyrin IX complex, is synthesised through an eight-step pathway beginning and ending in the mitochondrial matrix, with several cytosolic intermediates. Ferrochelatase catalyses ...

GLP-1 drugs have transformed weight loss by suppressing appetite. The other half of the equation — helping the body burn more energy — has received less attention. Focusing on metabolic studies in ...

Scientists at Washington University in St. Louis described for the first time the structure of a bifunctional protein, called CcsBA, that transports heme and attaches it to cytochromes. Credit: Kranz ...

Higher intake of heme iron, the type found in red meat and other animal products - as opposed to non-heme iron, found mostly in plant-based foods - was associated with a higher risk of developing type ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...