Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

癌症的本质很大程度上可以理解为一场基因组的 “内乱”。根据世界卫生组织国际癌症研究机构发布的数据，2022 年全球新发癌症病例接近 2000 万例，而几乎所有癌细胞都有一个共同特征——基因组不稳定性。这种不稳定的核心根源之一，正是 DNA 复制过程中频繁出现的 “复制压力”。当 DNA 双螺旋在高速复制时遭遇障碍、意外断裂，细胞必须立刻启动紧急修复程序，否则就会走向死亡，或是发生更严重的致癌突变。

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

Surprisingly, forcing an acceleration of replication forks led to miscoordination between genome replication completion and cell cycle progression. Dr. Tsubouchi concludes, "We propose that slow ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...