When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired ...

DNA-protein crosslinks (DPCs) are bulky lesions formed when proteins become covalently attached to DNA, arising from endogenous metabolism, environmental agents or the action of specialised enzymes ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors, ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for ...

Researchers found that cancer cells may repair chemotherapy-induced DNA damage, helping explain treatment resistance in ...

Chemotherapy drugs are designed to shatter tumor DNA so thoroughly that cancer cells cannot survive. But one of the most ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression. Research has identified a critical DNA repair ...