For biologists, DNA microarrays present at once unprecedented opportunities and monumental challenges. In the opportunities column, microarrays produce genome-wide gene expression snapshots, ...

Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of ...

Cells that acquire somatic mutations conferring a survival advantage can expand clonally, which in some cases leads to cancer. In the haematopoietic system — which is readily accessible through blood ...

The overall process begins with cDNA or oligonucleotides spotted in two-dimensional arrays onto glass slides or nylon membranes, or synthesized on biochips using technology borrowed from the ...