Large-scale genomic data are well suited to analysis by deep learning algorithms. However, for many genomic datasets, labels are at the level of the sample rather than for individual genomic measures.

• Dominant negative mutations impair nucleotide binding affinity to the extent that RAC1 forms a non-functional complex with its cognate GEFs in a nucleotide-free state. A dominant negative RAC1 ...

Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. Researchers, using an experiment that elucidated the function of tens of thousands of noncoding ...

Some genes are known to drive cancer, and astonishing new research shows why: Mutations in the noncoding regions become functional, altering the abundance of messenger RNA, or mRNA, and potentially ...

A signaling system known as the Wnt pathway plays a central role in how cells in the intestine grow, divide and renew ...